Highlights

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A 3D metaphase model reconstructed from confocal images of HeLa cells. The colors identify different elements/proteins important for mitosis.
Superresolution image of a nuclear pore (right) labeled with an antibody against the Nup107-160 complex. The image is gradually built up by localizing the centers of individual fluorophores switching between light-emitting and dark state (left).

Embryonic preimplantation development: Tracking of all cells throughout the first mitotic divisions from zygote to blastocyst stage (8- to 16-cell division shown here) using an inverted light-sheet microscope. Nuclei (H2B) are overlaid with spheres showing cell position, indicating trophoectoderm (TE; blue) or inner cell mass (ICM; red) fate.

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Introduction to the Group and its Research

Our group is an international interdisciplinary team drawing its members from biology, physics, chemistry, computer science, and engineering. The overarching theme of the lab is to understand the molecular mechanism of the nuclear division cycle in a comprehensive manner in the physiological context of the intact living cell. To achieve this we develop and use a braod range of fluorescence-based imaging technologies to assay the functions of the involved molecular machinery non-invasively, automate imaging to address all its molecular components and computationally process image data to extract biochemical and biophysical parameters in order to generate mechanistic understanding and predictive models. Our biological questions are currently focused on three areas.