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Mitotic spindle composed of thousands of microscopy images of human cells in which individual genes were silenced. Chromosomes (red) are made of images from genes that affect their segregation, while the mitotic spindle (green) is composed of images from genes affecting its assembly.
How an inner nuclear membrane protein coordinates nuclear envelope breakdown and spindle assembly

Tracking kinetochores throughout the first meiotic division of mouse oocytes.


Introduction to the Group and its Research

Our group is an international interdisciplinary team drawing its members from biology, physics, chemistry, computer science, and engineering. The overarching theme of the lab is to understand the molecular mechanism of the nuclear division cycle in a comprehensive manner in the physiological context of the intact living cell. To achieve this we develop and use a braod range of fluorescence-based imaging technologies to assay the functions of the involved molecular machinery non-invasively, automate imaging to address all its molecular components and computationally process image data to extract biochemical and biophysical parameters in order to generate mechanistic understanding and predictive models. Our biological questions are currently focused on three areas.